Our first publication of 2015! Nicotine, Curare, and Planarians, oh my…

reblogging

Baldscientist

I am very proud to announce the e-publication of our first paper of 2015! It was published in the journal Neurochemical Research.

Here’s the release:

Neurochem Res. 2015 Jan 23. [Epub ahead of print]

Evidence of Nicotine-Induced, Curare-Insensitive, Behavior in Planarians.

Pagán OR, Montgomery E, Deats S, Bach D, Baker D.

Department of Biology, West Chester University, West Chester, PA, 19383, USA, opagan@wcupa.edu.

Abstract
Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and curare (1 mM), while curare alone does not induce significant pSLMs. The simplest interpretation of our data is that there are nicotine induced behaviors insensitive to curare in our experimental organism. To the best of our knowledge, this is the first report on…

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